{"id":21500,"date":"2024-06-12T18:06:00","date_gmt":"2024-06-12T16:06:00","guid":{"rendered":"https:\/\/mediaire.ai\/?p=21500"},"modified":"2025-09-03T09:04:39","modified_gmt":"2025-09-03T07:04:39","slug":"automatic-lesion-detection-at-multiple-sclerosis-patients-comparison-of-2d-and-3d-flair-datasets","status":"publish","type":"post","link":"https:\/\/mediaire.ai\/en\/automatic-lesion-detection-at-multiple-sclerosis-patients-comparison-of-2d-and-3d-flair-datasets\/","title":{"rendered":"Automatic lesion detection at Multiple Sclerosis patients \u2013 Comparison of 2D- and 3D-FLAIR-datasets"},"content":{"rendered":"
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Multiple Sclerosis and Related Disorders 88<\/em> (2024), https:\/\/doi.org\/10.1016\/j.msard.2024.105728<\/p>\n

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Authors<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Seehafer, S., Schmill, L. P., Aludin, S., Huhndorf, M., Larsen, N., Jansen, O., St\u00fcrner, K., Peters, S.<\/p>\n

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Abstract<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Background<\/h3>\n

Multiple Sclerosis (MS) is a common autoimmune inflammatory disease of the central nervous system (CNS). Magnetic Resonance Imaging (MRI) allows a sensitive assessment of the CNS and is established for diagnostic, prognostic and (therapy-) monitoring purposes. Especially lesion counting in T2- or Fluid Attenuated Inversion Recovery (FLAIR)-weighted images plays a decisive role in clinical routine. Software-packages allowing an automatic evaluation of image data are increasingly established aiming a faster and improved workflow. These programs allow e.g. the counting, spatial attribution and volumetry of MS-lesions in FLAIR-weighted images. Research has shown that 3D-FLAIR-sequences are superior to 2D-FLAIR-sequences in visual evaluation of lesion burden in MS. An influence on the automatic analysis is expectable but not yet systematically studied. This work will therefore investigate the influence of 2D- and 3D datasets on the results of an automatic assessment.<\/p>\n

Material and methods<\/h3>\n

In this prospective study, 80 Multiple Sclerosis patients underwent a clinically indicated routine MRI examination. The clinical routine protocol already including a 3D-FLAIR sequence was adapted by an additional 2D-FLAIR sequence also conform to the 2021 MAGNIMS-CMSC NAIMS consensus recommendations. To obtain a quantitative analysis for assessment of amount, dissemination and volume of the lesions, the acquired MR images were post-processed using the CE-certified Software mdbrain (mediaire, Berlin, Germany). The resulting data were statistically analysed using the paired t-test for normally distributed data and the Wilcoxon-signed-rank-test for not normally distributed data respectively. Demographic data and data such as the subtype, duration, severity and therapy of the disease were collected, pseudonymized and evaluated.<\/p>\n

Results<\/h3>\n

There is a significant difference concerning the total number and lesion volume with more lesions being detected (2D: 29.7, +\/- 20.22 sd; 3D: 40.1 +\/- 31.67 sd; p < 0.0001) but lower total volume (2D: 6.24 +\/- 6.11 sd; 3D: 5.39 +\/- 6.37 sd; p < 0.0001) when using the 3D- sequence. Especially significantly more small lesions in the unspecific white matter and infratentorial region were detected by using the 3D-FLAIR sequence (p < 0.0001) compared to the 2D-FLAIR image. Main reason for the lower total volume in the 3D-FLAIR sequence was the calculated volume for periventricular lesions which was significantly beneath the calculated volume from the 2D-FLAIR sequence (p < 0.0001).<\/p>\n

Conclusion<\/h3>\n

Automatic lesion counting and volumetry is feasible with both 2D- and 3D-weightend FLAIR images. Still, it leads to partly significant differences even between two sequences that both are conform to the 2021 MAGNIMS-CMSC NAIMS consensus recommendations. This study contributes valuable insights into the impact of using different input data from the same patient for automated MS lesion evaluation.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Multiple Sclerosis (MS) is a common autoimmune inflammatory disease of the central nervous system (CNS). Magnetic Resonance Imaging (MRI) allows a sensitive assessment of the CNS and is established for diagnostic, prognostic and (therapy-) monitoring purposes.<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[14],"tags":[],"class_list":["post-21500","post","type-post","status-publish","format-standard","hentry","category-publications"],"acf":[],"_links":{"self":[{"href":"https:\/\/mediaire.ai\/en\/wp-json\/wp\/v2\/posts\/21500","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mediaire.ai\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mediaire.ai\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mediaire.ai\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/mediaire.ai\/en\/wp-json\/wp\/v2\/comments?post=21500"}],"version-history":[{"count":6,"href":"https:\/\/mediaire.ai\/en\/wp-json\/wp\/v2\/posts\/21500\/revisions"}],"predecessor-version":[{"id":21624,"href":"https:\/\/mediaire.ai\/en\/wp-json\/wp\/v2\/posts\/21500\/revisions\/21624"}],"wp:attachment":[{"href":"https:\/\/mediaire.ai\/en\/wp-json\/wp\/v2\/media?parent=21500"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mediaire.ai\/en\/wp-json\/wp\/v2\/categories?post=21500"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mediaire.ai\/en\/wp-json\/wp\/v2\/tags?post=21500"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}